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The underappreciated diversity of bile acid modifications.
Mohanty, Ipsita; Mannochio-Russo, Helena; Schweer, Joshua V; El Abiead, Yasin; Bittremieux, Wout; Xing, Shipei; Schmid, Robin; Zuffa, Simone; Vasquez, Felipe; Muti, Valentina B; Zemlin, Jasmine; Tovar-Herrera, Omar E; Moraïs, Sarah; Desai, Dhimant; Amin, Shantu; Koo, Imhoi; Turck, Christoph W; Mizrahi, Itzhak; Kris-Etherton, Penny M; Petersen, Kristina S; Fleming, Jennifer A; Huan, Tao; Patterson, Andrew D; Siegel, Dionicio; Hagey, Lee R; Wang, Mingxun; Aron, Allegra T; Dorrestein, Pieter C.
Afiliación
  • Mohanty I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Mannochio-Russo H; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Schweer JV; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA, USA.
  • El Abiead Y; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Bittremieux W; Department of Computer Science, University of Antwerp, 2020 Antwerpen, Belgium.
  • Xing S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Department of Chemistry, Faculty of Science, University of British Columbia, Vancouver Campus, Vancouver, BC, Canada.
  • Schmid R; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
  • Zuffa S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Vasquez F; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Muti VB; Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA, USA; Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80210, USA.
  • Zemlin J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Tovar-Herrera OE; Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel; Goldman Sonnenfeldt School of Sustainability and Climate Change, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
  • Moraïs S; Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel; Goldman Sonnenfeldt School of Sustainability and Climate Change, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
  • Desai D; Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA.
  • Amin S; Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA.
  • Koo I; Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.
  • Turck CW; Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Kraepelinstrasse 2-10, Munich 80804, Germany; Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China.
  • Mizrahi I; Department of Life Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel; Goldman Sonnenfeldt School of Sustainability and Climate Change, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.
  • Kris-Etherton PM; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
  • Petersen KS; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
  • Fleming JA; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
  • Huan T; Department of Chemistry, Faculty of Science, University of British Columbia, Vancouver Campus, Vancouver, BC, Canada.
  • Patterson AD; Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA.
  • Siegel D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
  • Hagey LR; Department of Medicine, University of California, San Diego, San Diego, CA, USA.
  • Wang M; Department of Computer Science and Engineering, University of California, Riverside, Riverside, CA, USA.
  • Aron AT; Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80210, USA.
  • Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA; Department of Pharmacology,
Cell ; 187(7): 1801-1818.e20, 2024 Mar 28.
Article en En | MEDLINE | ID: mdl-38471500
ABSTRACT
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource of tandem mass spectrometry (MS/MS) spectra by filtering 1.2 billion publicly available MS/MS spectra for bile-acid-selective ion patterns. Thousands of modifications are distributed throughout animal and human bodies as well as microbial cultures. We employed this MS/MS library to identify polyamine bile amidates, prevalent in carnivores. They are present in humans, and their levels alter with a diet change from a Mediterranean to a typical American diet. This work highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover metabolites. The availability of a modification-centric bile acid MS/MS library will inform future studies investigating bile acid roles in health and disease.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Espectrometría de Masas en Tándem / Metabolómica / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Espectrometría de Masas en Tándem / Metabolómica / Microbioma Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Cell Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos