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APOE ε4 is associated with decreased synaptic density in cognitively impaired participants.
He, Kun; Li, Binyin; Wang, Jie; Wang, Ying; You, Zhiwen; Chen, Xing; Chen, Haijuan; Li, Junpeng; Huang, Qi; Guo, Qihao; Huang, Yiyun Henry; Guan, Yihui; Chen, Kewei; Zhao, Jun; Deng, Yulei; Xie, Fang.
Afiliación
  • He K; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Li B; Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang J; Clinical Neuroscience Center, Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
  • You Z; Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Chen X; Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Chen H; Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Li J; Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Huang Q; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Guo Q; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Huang YH; Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Guan Y; PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, USA.
  • Chen K; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhao J; Banner Alzheimer Institute, Arizona State University, University of Arizona and Arizona Alzheimer's Consortium, Phoenix, USA.
  • Deng Y; Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Xie F; Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Alzheimers Dement ; 20(5): 3157-3166, 2024 05.
Article en En | MEDLINE | ID: mdl-38477490
ABSTRACT

INTRODUCTION:

We aimed to investigate the effect of apolipoprotein E4 (APOE) ε4 on synaptic density in cognitively impaired (CI) participants.

METHODS:

One hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18F-florbetapir and synaptic density PET with 18F-SynVesT-1. We evaluated the influence of APOE ε4 allele on synaptic density and investigated the effects of ε4 genotype on the associations of synaptic density with Alzheimer's disease (AD) biomarkers. The mediation effects of AD biomarkers on ε4-associated synaptic density loss were analyzed.

RESULTS:

Compared with non-carriers, APOE ε4 allele carriers exhibited significant synaptic loss in the medial temporal lobe. Amyloid beta (Aß) and tau pathology mediated the effects of APOE ε4 on synaptic density to different extents. The associations between synaptic density and tau pathology were regulated by the APOE ε4 genotype.

DISCUSSION:

The APOE ε4 allele was associated with decreased synaptic density in CI individuals and may be driven by AD biomarkers.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sinapsis / Péptidos beta-Amiloides / Tomografía de Emisión de Positrones / Apolipoproteína E4 / Disfunción Cognitiva Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sinapsis / Péptidos beta-Amiloides / Tomografía de Emisión de Positrones / Apolipoproteína E4 / Disfunción Cognitiva Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: China