A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition.

Zhang, Yuanmeng; Lin, Muyang; Yao, Jingkang; Xu, Xiaowen

Zhang, Yuanmeng; Lin, Muyang; Yao, Jingkang; Xu, Xiaowen.

Afiliación

Zhang Y; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. xuxw@sdu.edu.cn.
Lin M; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. xuxw@sdu.edu.cn.
Yao J; Taishan College, Shandong University, Jinan 250100, P. R. China.
Xu X; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. xuxw@sdu.edu.cn.

Chem Commun (Camb) ; 60(27): 3721-3724, 2024 Mar 28.

Article en En | MEDLINE | ID: mdl-38482771

ABSTRACT

ABSTRACT

Here, we report a DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition. The DNA tetrahedron dimer not only detects dual proteins that are both overexpressed on target cells in "AND" logic, but also inhibits protein interaction by steric hindrance to suppress cell proliferation, offering new insights for cancer cell diagnosis and treatment.

Asunto(s)

ADN; Proteínas de la Membrana; Lógica

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / Proteínas de la Membrana Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article

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