Protein-membrane interactions: sensing and generating curvature.
Trends Biochem Sci
; 49(5): 401-416, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38508884
ABSTRACT
Biological membranes are integral cellular structures that can be curved into various geometries. These curved structures are abundant in cells as they are essential for various physiological processes. However, curved membranes are inherently unstable, especially on nanometer length scales. To stabilize curved membranes, cells can utilize proteins that sense and generate membrane curvature. In this review, we summarize recent research that has advanced our understanding of interactions between proteins and curved membrane surfaces, as well as work that has expanded our ability to study curvature sensing and generation. Additionally, we look at specific examples of cellular processes that require membrane curvature, such as neurotransmission, clathrin-mediated endocytosis (CME), and organelle biogenesis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Membrana Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos