Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila.
Dev Biol
; 511: 1-11, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38548146
ABSTRACT
Maintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown decreased exercise capacity and produced sarcopenic phenotypes. In addition, it increased the apoptosis rate because of the elevated reactive oxygen species production resulting from mitochondrial dysfunction. Moreover, the autophagy rate increased due to increased FoxO activity caused by reduced Akt activity. Collectively, these findings demonstrate that enhanced apoptosis and autophagy rates resulting from muscle-specific Pss knockdown jointly contribute to sarcopenia development, highlighting the key role of the PSS pathway in muscle health.
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Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Atrofia Muscular
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Especies Reactivas de Oxígeno
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Apoptosis
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Proteínas de Drosophila
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Drosophila melanogaster
Límite:
Animals
Idioma:
En
Revista:
Dev Biol
Año:
2024
Tipo del documento:
Article