The emerging role of lactate in tumor microenvironment and its clinical relevance.
Cancer Lett
; 590: 216837, 2024 May 28.
Article
en En
| MEDLINE
| ID: mdl-38548215
ABSTRACT
In recent years, the significant impact of lactate in the tumor microenvironment has been greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is also an imperative signaling molecule. It plays key roles in metabolic remodeling, protein lactylation, immunosuppression, drug resistance, epigenetics and tumor metastasis, which has a tight relation with cancer patients' poor prognosis. This review illustrates the roles lactate plays in different aspects of tumor progression and drug resistance. From the comprehensive effects that lactate has on tumor metabolism and tumor immunity, the therapeutic targets related to it are expected to bring new hope for cancer therapy.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Resistencia a Antineoplásicos
/
Ácido Láctico
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Microambiente Tumoral
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2024
Tipo del documento:
Article