Living in Syn: T Cell Antigen Identification Based on Synapse Sequencing.
Cancer Immunol Res
; 12(5): 515, 2024 May 02.
Article
en En
| MEDLINE
| ID: mdl-38557780
ABSTRACT
The pivotal role of T cell responses has been well studied in both protective and destructive scenarios. T cells recognize peptide epitopes presented on Human Leukocyte Antigens (HLA) through their surface T cell receptors (TCR). Advances in single-cell RNA sequencing have identified millions of TCRs, but only a minuscule fraction of them have known epitopes. Recently, cell-based T cell antigen discovery platforms have emerged onto the landscape. Here, Jin and colleagues, report a novel antigen discovery platform called Tsyn-seq that relies on sequencing TCR-peptide-HLA-induced synapses for genome-wide epitope screening. See related article by Jin et al., p. 530 (3).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
Límite:
Humans
Idioma:
En
Revista:
Cancer Immunol Res
Año:
2024
Tipo del documento:
Article