Bioguided isolation, identification and bioactivity evaluation of anti-fatigue constituents from Schizophyllum commune.
Fitoterapia
; 175: 105940, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38565382
ABSTRACT
This study aims to clarify the specific anti-fatigue components of Schizophyllum commune (S.commune) and analyze its potential anti-fatigue mechanism. The main anti-fatigue active ingredient of S.commune was locked in n-butanol extract (SPE-n) by activity evaluation. Twelve compounds were identified by high performance liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). The anti-fatigue effect of morusin is the most predominant among these 12 ingredients. The determination of biochemical indices showed that morusin could increase liver glycogen reserves, improve the activity of antioxidant enzymes in liver, and reduce reactive oxygen species (ROS) content in muscle tissue, thereby reducing myocyte damage. Further studies revealed that morusin could reduce the level of oxidative stress by activating Nrf2/HO-1 pathway, thus alleviating the fatigue of mice caused by exhaustive exercise. The current findings provide a theoretical basis for the development of natural anti-fatigue functional food.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Schizophyllum
/
Fatiga
Límite:
Animals
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article
País de afiliación:
China