The mechanistic basis linking cytokine storm to thrombosis in COVID-19.
Thromb Update
; 8: 100110, 2022 Aug.
Article
en En
| MEDLINE
| ID: mdl-38620974
ABSTRACT
It is now well established that infection with SARS-CoV-2 resulting in COVID-19 disease includes a severely symptomatic subset of patients in whom an aggressive and/or dysregulated host immune response leads to cytokine storm syndrome (CSS) that may be further complicated by thrombotic events, contributing to the severe morbidity and mortality observed in COVID-19. This review provides a brief overview of cytokine storm in COVID-19, and then presents a mechanistic discussion of how cytokine storm affects integrated pathways in thrombosis involving the endothelium, platelets, the coagulation cascade, eicosanoids, auto-antibody mediated thrombosis, and the fibrinolytic system.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
Thromb Update
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos