Clinical phenotypes of comorbidities in end-stage knee osteoarthritis: a cluster analysis.
BMC Musculoskelet Disord
; 25(1): 299, 2024 Apr 17.
Article
en En
| MEDLINE
| ID: mdl-38627663
ABSTRACT
OBJECTIVES:
Comorbidities, as components of these heterogeneous features, often coexist with knee osteoarthritis, and are particularly prevalent in end-stage knee osteoarthritis. Here, we attempted to identify the different clinical phenotypes of comorbidities in patients with end-stage knee osteoarthritis by cluster analysis.METHODS:
A total of 421 inpatients diagnosed with end-stage knee osteoarthritis who underwent inpatient surgery were included in this cross-sectional study. 23 demographic, comorbidity, inflammatory immune and evaluation scale variables were collected. Systematic clustering after factor analysis and separate two-step cluster analysis were performed for individual comorbidity variables and all variables, respectively, to objectively identify the different clinical phenotypes of the study patients.RESULTS:
Four clusters were finally identified. Cluster 1 had the largest proportion of obese patients (93.8%) and hypertension was common (71.2%). Almost all patients in cluster 2 were depressed (95.8%) and anxiety disorders (94.7%). Cluster 3 combined patients with isolated end-stage knee osteoarthritis and a few comorbidities. Cluster 4 had the highest proportion of patients with rheumatoid arthritis (58.8%).CONCLUSIONS:
Patients with end-stage knee osteoarthritis may be classified into four different clinical phenotypes "isolated end-stage knee osteoarthritis"; "obesity + hypertension"; "depression + anxiety"; and "rheumatoid arthritis", which may help guide individualized patient care and treatment strategies.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Osteoartritis de la Rodilla
/
Hipertensión
Límite:
Humans
Idioma:
En
Revista:
BMC Musculoskelet Disord
Asunto de la revista:
FISIOLOGIA
/
ORTOPEDIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China