Clinical Presentation and Spectrum of Gluten Symptomatology in Celiac Disease.
Gastroenterology
; 167(1): 51-63, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38636679
ABSTRACT
Views on the clinical presentation and symptomatology of celiac disease have evolved alongside advances in disease detection and understanding of disease pathogenesis. Although historically regarded as a pediatric illness characterized by malabsorption, it is now better viewed as an immune illness of gluten-specific T cells with systemic manifestations affecting all ages. Its broad presentation, including frequent extraintestinal manifestations and asymptomatic disease, contributes to suboptimal disease detection. Adverse symptoms greatly impact patient quality of life and can result from chronic gluten exposure in untreated disease or those poorly responsive to the gluten-free diet. They can also present as acute symptoms after episodic gluten exposure. Functional gastrointestinal disease is a common comorbidity. Biomarkers like interleukin-2 that are highly sensitive and specific for celiac disease highlight a role for gluten-specific T cells in acute gluten symptomatology. A mechanistic understanding of symptoms will inform approaches to better measure and treat them effectively.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad Celíaca
/
Dieta Sin Gluten
/
Glútenes
Límite:
Humans
Idioma:
En
Revista:
Gastroenterology
Año:
2024
Tipo del documento:
Article