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Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer.
Bourel, Capucine; Lesage, Sylvie.
Afiliación
  • Bourel C; Immunologie-oncologie, Centre de recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
  • Lesage S; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, QC, Canada.
Immunol Cell Biol ; 102(6): 441-443, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38670548
ABSTRACT
In this article for the Highlights of 2023 Series, we discuss how various factors affect the ability of natural killer (NK) cells to fight tumors. For instance, tumor cells can hinder NK cell function by reducing surface protrusions or increasing HLA-E expression via platelets. Lower UTX protein levels in male NK cells also decrease their cytotoxicity compared with females. Fortunately, recent advancements in therapeutic approaches have emerged, including the development of a comprehensive atlas of NK cell heterogeneity within the tumor microenvironment, as well as a trispecific engager molecule that has shown promise in enhancing the anti-tumor functions of NK cells.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Microambiente Tumoral / Neoplasias Límite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Microambiente Tumoral / Neoplasias Límite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá