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Lifestyle and incident dementia: A COSMIC individual participant data meta­analysis.
Van Asbroeck, Stephanie; Köhler, Sebastian; van Boxtel, Martin P J; Lipnicki, Darren M; Crawford, John D; Castro-Costa, Erico; Lima-Costa, Maria Fernanda; Blay, Sergio Luis; Shifu, Xiao; Wang, Tao; Yue, Ling; Lipton, Richard B; Katz, Mindy J; Derby, Carol A; Guerchet, Maëlenn; Preux, Pierre-Marie; Mbelesso, Pascal; Norton, Joanna; Ritchie, Karen; Skoog, Ingmar; Najar, Jenna; Sterner, Therese Rydberg; Scarmeas, Nikolaos; Yannakoulia, Mary; Dardiotis, Themis; Rolandi, Elena; Davin, Annalisa; Rossi, Michele; Gureje, Oye; Ojagbemi, Akin; Bello, Toyin; Kim, Ki Woong; Han, Ji Won; Oh, Dae Jong; Trompet, Stella; Gussekloo, Jacobijn; Riedel-Heller, Steffi G; Röhr, Susanne; Pabst, Alexander; Shahar, Suzana; Rivan, Nurul Fatin Malek; Singh, Devinder Kaur Ajit; Jacobsen, Erin; Ganguli, Mary; Hughes, Tiffany; Haan, Mary; Aiello, Allison E; Ding, Ding; Zhao, Qianhua; Xiao, Zhenxu.
Afiliación
  • Van Asbroeck S; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
  • Köhler S; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
  • van Boxtel MPJ; Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
  • Lipnicki DM; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Crawford JD; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
  • Castro-Costa E; René Rachou Institute, Fiocruz Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Lima-Costa MF; René Rachou Institute, Fiocruz Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Blay SL; Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.
  • Shifu X; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang T; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yue L; Department of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lipton RB; Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.
  • Katz MJ; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Derby CA; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Guerchet M; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Preux PM; Department of Psychiatry and Behavioral Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Mbelesso P; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Norton J; Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Ritchie K; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Skoog I; Inserm U1094, IRD UMR270, University Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
  • Najar J; Inserm U1094, IRD UMR270, University Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
  • Sterner TR; Department of Neurology, Amitié Hospital, Bangui, Central African Republic.
  • Scarmeas N; Institute for Neurosciences of Montpellier (INM), University of Montpellier, Inserm, Montpellier, France.
  • Yannakoulia M; Institute for Neurosciences of Montpellier (INM), University of Montpellier, Inserm, Montpellier, France.
  • Dardiotis T; Institut du Cerveau Trocadéro, Paris, France.
  • Rolandi E; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of Gothenburg, Gothenburg, Sweden.
  • Davin A; Centre for Ageing and Health (AGECAP), University of Gothenburg, Gothenburg, Sweden.
  • Rossi M; Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.
  • Gureje O; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of Gothenburg, Gothenburg, Sweden.
  • Ojagbemi A; Centre for Ageing and Health (AGECAP), University of Gothenburg, Gothenburg, Sweden.
  • Bello T; Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.
  • Kim KW; Department of Clinical Genetics, Section Genomics of Neurodegenerative Diseases and Aging, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
  • Han JW; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of Gothenburg, Gothenburg, Sweden.
  • Oh DJ; Centre for Ageing and Health (AGECAP), University of Gothenburg, Gothenburg, Sweden.
  • Trompet S; Department of Neurobiology, Aging Research Center, Care Sciences and Society, Karolinska Institute and Stockholm University, Stockholm, Sweden.
  • Gussekloo J; 1st Department of Neurology, Aiginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Riedel-Heller SG; Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
  • Röhr S; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
  • Pabst A; School of Medicine, University of Thessaly, Larissa, Greece.
  • Shahar S; Golgi Cenci Foundation, Milan, Italy.
  • Rivan NFM; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Singh DKA; Golgi Cenci Foundation, Milan, Italy.
  • Jacobsen E; Golgi Cenci Foundation, Milan, Italy.
  • Ganguli M; Department of Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Neuroscience and Substance Abuse, University of Ibadan, Ibadan, Nigeria.
  • Hughes T; Department of Psychiatry, College of Medicine University of Ibadan, Ibadan, Nigeria.
  • Haan M; Department of Psychiatry, College of Medicine University of Ibadan, Ibadan, Nigeria.
  • Aiello AE; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Ding D; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Zhao Q; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
  • Xiao Z; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Alzheimers Dement ; 20(6): 3972-3986, 2024 06.
Article en It | MEDLINE | ID: mdl-38676366
ABSTRACT

INTRODUCTION:

The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.

METHODS:

We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.

RESULTS:

A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed.

DISCUSSION:

Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Demencia / Estilo de Vida Límite: Aged / Female / Humans / Male Idioma: It Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Demencia / Estilo de Vida Límite: Aged / Female / Humans / Male Idioma: It Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos