Can the HB-EGF/EGFR pathway restore injured neurons?
FEBS J
; 291(10): 2094-2097, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38680125
ABSTRACT
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a transmembrane protein that, when cleaved by metalloproteases through a process called ectodomain shedding, binds to the EGF receptor (EGFR), activating downstream signaling. The HB-EGF/EGFR pathway is crucial in development and is involved in numerous pathophysiological processes. In this issue of The FEBS Journal, Sireci et al. reveal a previously unexplored function of the HB-EGF/EGFR pathway in promoting neuronal progenitor proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium in response to injury.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pez Cebra
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Transducción de Señal
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Receptores ErbB
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Factor de Crecimiento Similar a EGF de Unión a Heparina
Límite:
Animals
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Humans
Idioma:
En
Revista:
FEBS J
/
FEBS j
/
FEBS journal
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Portugal