Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer.

Smith, Timothy J; Elmore, Zachary C; Fusco, Robert M; Hull, Joshua A; Rosales, Alan; Martinez, Michele; Tarantal, Alice F; Asokan, Aravind

Smith, Timothy J; Elmore, Zachary C; Fusco, Robert M; Hull, Joshua A; Rosales, Alan; Martinez, Michele; Tarantal, Alice F; Asokan, Aravind.

Afiliación

Smith TJ; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Elmore ZC; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Fusco RM; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Hull JA; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Rosales A; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Martinez M; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, and California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Tarantal AF; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, and California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Asokan A; Department of Molecular Genetics & Microbiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address: aravind.

Mol Ther ; 32(7): 2080-2093, 2024 Jul 03.

Article en En | MEDLINE | ID: mdl-38715362

Asunto(s)

Activación de Complemento; Dependovirus; Vectores Genéticos; Inmunoglobulina G; Inmunoglobulina M; Dependovirus/genética; Dependovirus/inmunología; Animales; Inmunoglobulina M/inmunología; Humanos; Inmunoglobulina G/inmunología; Ratones; Vectores Genéticos/genética; Vectores Genéticos/administración & dosificación; Anticuerpos Neutralizantes/inmunología; Transducción Genética; Técnicas de Transferencia de Gen; Anticuerpos Antivirales/inmunología; Proteolisis; Terapia Genética/métodos; Ingeniería de Proteínas

Palabras clave

AAV; B cell; IMR; IgG; IgM; adeno-associated virus; complement activation; gene therapy; immune modulatory regimens

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inmunoglobulina G / Inmunoglobulina M / Dependovirus / Activación de Complemento / Vectores Genéticos Límite: Animals / Humans Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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