Effect of grape-derived products on the serum levels of enzymes mainly produced by the liver: A systematic review and meta-analysis of parallel randomized controlled trials.
Phytother Res
; 38(7): 3583-3593, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38719548
ABSTRACT
In recent years, an increase in the incidence of liver diseases has been reported all over the world. This study aims to comprehensively summarize and quantitatively analyze the existing evidence concerning the effectiveness of grape-derived products on liver enzymes through a systematic review and meta-analytic approach. PubMed, Scopus, Cochrane Library, and ISI Web of Science were comprehensively searched until January 2024. Articles that reported the effect of grape-derived products on serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were included. Weighted mean differences (WMDs) were pooled using a random-effects model. Nine studies were included in the meta-analysis. The results revealed that grape-derived products did not significantly change the concentrations of ALT (WMD -2.70 IU/L, 95% CI -6.14 to 0.75, p = 0.12), and AST (WMD -1.42 IU/L, 95% CI -3.54 to 0.70, p = 0.18). However, a significant reduction was observed in serum ALP levels (WMD -5.49 IU/L, 95% CI -9.57 to -1.4, p = 0.008). The present findings suggest that grape-derived products positively influence serum ALP levels among adults. However, a more comprehensive decision necessitates additional studies.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aspartato Aminotransferasas
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Ensayos Clínicos Controlados Aleatorios como Asunto
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Vitis
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Alanina Transaminasa
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Fosfatasa Alcalina
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Hígado
Límite:
Humans
Idioma:
En
Revista:
Phytother Res
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2024
Tipo del documento:
Article
País de afiliación:
Arabia Saudita