ML3CNet: Non-local means-assisted automatic framework for lung cancer subtypes classification using histopathological images.

ABSTRACT

BACKGROUND AND OBJECTIVE: Lung cancer (LC) has a high fatality rate that continuously affects human lives all over the world. Early detection of LC prolongs human life and helps to prevent the disease. Histopathological inspection is a common method to diagnose LC. Visual inspection of histopathological diagnosis necessitates more inspection time, and the decision depends on the subjective perception of clinicians. Usually, machine learning techniques mostly depend on traditional feature extraction which is labor-intensive and may not be appropriate for enormous data. In this work, a convolutional neural network (CNN)-based architecture is proposed for the more effective classification of lung tissue subtypes using histopathological images. METHODS: Authors have utilized the first-time nonlocal mean (NLM) filter to suppress the effect of noise from histopathological images. NLM filter efficiently eliminated noise while preserving the edges of images. Then, the obtained denoised images are given as input to the proposed multi-headed lung cancer classification convolutional neural network (ML3CNet). Furthermore, the model quantization technique is utilized to reduce the size of the proposed model for the storage of the data. Reduction in model size requires less memory and speeds up data processing. RESULTS: The effectiveness of the proposed model is compared with the other existing state-of-the-art methods. The proposed ML3CNet achieved an average classification accuracy of 99.72%, sensitivity of 99.66%, precision of 99.64%, specificity of 99.84%, F-1 score of 0.9965, and area under the curve of 0.9978. The quantized accuracy of 98.92% is attained by the proposed model. To validate the applicability of the proposed ML3CNet, it has also been tested on the colon cancer dataset. CONCLUSION: The findings reveal that the proposed approach can be beneficial to automatically classify LC subtypes that might assist healthcare workers in making decisions more precisely. The proposed model can be implemented on the hardware using Raspberry Pi for practical realization.