Synthesis and anti-inflammatory activity of mogrol derivatives modified at C24 site.
Fitoterapia
; 176: 106005, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38744383
ABSTRACT
Mogrol, the aglycone of well-known sweeter mogrosides, shows potent anti-inflammatory activity. In this study, forty-two mogrol derivatives bearing various pharmacophores with oxygen or nitrogen atoms were designed and synthesized via structural modification at C24 site, and their anti-inflammatory activity were screened against lipopolysaccharide (LPS)-induced RAW264.7 cells. Compared with mogrol, most of derivatives exhibited stronger inhibition of NO production without cytotoxicity. In particular, compound B5 that contained an indole motif effectively suppressed the secretion of inflammatory mediators including TNF-α and IL-6, and inhibited the expression levels of TLR4, p-p65 and iNOS proteins. Molecular docking showed that the active B5 interacted with amino acid residues of iNOS protein through π-π stacking and hydrophobic interactions with binding affinity value of -12.1 kcal/mol, which was much stronger than mogrol (-8.9 kcal/mol). These results suggest that derivative B5 is a promising anti-inflammatory molecule and the strategy of hybridizing indole skeleton on mogrol is worthy for further attention.
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Bases de datos:
MEDLINE
Asunto principal:
Simulación del Acoplamiento Molecular
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article