Tumor targeted porphyrin-based metal-organic framework for photodynamic and checkpoint blockade immunotherapy.
Colloids Surf B Biointerfaces
; 239: 113965, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38772084
ABSTRACT
Photodynamic therapy (PDT) has become a promising approach and non-invasive modality for cancer treatment, however the therapeutic effect of PDT is limited in tumor metastasis and local recurrence. Herein, a tumor targeted nanomedicine (designated as PCN@HA) is constructed for enhanced PDT against tumors. By modified with hyaluronic acid (HA), which could target the CD44 receptor that expressed on the cancer cells, the targeting ability of PCN@HA has been enhanced. Under light irradiation, PCN@HA can produce cytotoxic singlet oxygen (1O2) and kill cancer cells, then eliminate tumors. Furthermore, PCN@HA exhibits fluorescence (FL)/ photoacoustic (PA) effects for multimodal imaging-guided cancer treatment. And PCN@HA-mediated PDT also can induce immunogenic cell death (ICD) and stimulate adaptive immune responses by releasing of tumor antigens. By combining with anti-PD-L1 checkpoint blockade therapy, it can not only effectively suppress the growth of primary tumor, but also inhibit the metastatic tumor growth.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
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Porfirinas
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Estructuras Metalorgánicas
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Ácido Hialurónico
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Inmunoterapia
Límite:
Animals
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Humans
Idioma:
En
Revista:
Colloids Surf B Biointerfaces
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article