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Transcranial volumetric imaging using a conformal ultrasound patch.
Zhou, Sai; Gao, Xiaoxiang; Park, Geonho; Yang, Xinyi; Qi, Baiyan; Lin, Muyang; Huang, Hao; Bian, Yizhou; Hu, Hongjie; Chen, Xiangjun; Wu, Ray S; Liu, Boyu; Yue, Wentong; Lu, Chengchangfeng; Wang, Ruotao; Bheemreddy, Pranavi; Qin, Siyu; Lam, Arthur; Wear, Keith A; Andre, Michael; Kistler, Erik B; Newell, David W; Xu, Sheng.
Afiliación
  • Zhou S; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Gao X; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Park G; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Yang X; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Qi B; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Lin M; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Huang H; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Bian Y; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Hu H; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Chen X; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Wu RS; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Liu B; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Yue W; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Lu C; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
  • Wang R; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Bheemreddy P; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
  • Qin S; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
  • Lam A; Department of Anesthesiology and Critical Care, University of California San Diego, La Jolla, CA, USA.
  • Wear KA; U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Andre M; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Kistler EB; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
  • Newell DW; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Xu S; Department of Neurosurgery, Seattle Neuroscience Institute, Seattle, WA, USA.
Nature ; 629(8013): 810-818, 2024 May.
Article en En | MEDLINE | ID: mdl-38778234
ABSTRACT
Accurate and continuous monitoring of cerebral blood flow is valuable for clinical neurocritical care and fundamental neurovascular research. Transcranial Doppler (TCD) ultrasonography is a widely used non-invasive method for evaluating cerebral blood flow1, but the conventional rigid design severely limits the measurement accuracy of the complex three-dimensional (3D) vascular networks and the practicality for prolonged recording2. Here we report a conformal ultrasound patch for hands-free volumetric imaging and continuous monitoring of cerebral blood flow. The 2 MHz ultrasound waves reduce the attenuation and phase aberration caused by the skull, and the copper mesh shielding layer provides conformal contact to the skin while improving the signal-to-noise ratio by 5 dB. Ultrafast ultrasound imaging based on diverging waves can accurately render the circle of Willis in 3D and minimize human errors during examinations. Focused ultrasound waves allow the recording of blood flow spectra at selected locations continuously. The high accuracy of the conformal ultrasound patch was confirmed in comparison with a conventional TCD probe on 36 participants, showing a mean difference and standard deviation of difference as -1.51 ± 4.34 cm s-1, -0.84 ± 3.06 cm s-1 and -0.50 ± 2.55 cm s-1 for peak systolic velocity, mean flow velocity, and end diastolic velocity, respectively. The measurement success rate was 70.6%, compared with 75.3% for a conventional TCD probe. Furthermore, we demonstrate continuous blood flow spectra during different interventions and identify cascades of intracranial B waves during drowsiness within 4 h of recording.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Velocidad del Flujo Sanguíneo / Encéfalo / Circulación Cerebrovascular / Ultrasonografía Límite: Adult / Humans Idioma: En Revista: Nature Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Velocidad del Flujo Sanguíneo / Encéfalo / Circulación Cerebrovascular / Ultrasonografía Límite: Adult / Humans Idioma: En Revista: Nature Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos