Predictive value of spectral computed tomography parameters for EGFR gene mutation in non-small-cell lung cancer.
Clin Radiol
; 79(8): e1049-e1056, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38797609
ABSTRACT
AIM:
To explore the predictive value of morphological signs and quantitative parameters from spectral CT for EGFR gene mutations in intermediate and advanced non-small-cell lung cancer (NSCLC). MATERIALS ANDMETHODS:
This retrospective observational study included patients with intermediate or advanced NSCLC at Xinjiang Medical University Affiliated Tumor Hospital between January 2017 and December 2019. The patients were divided into the EGFR gene mutation-positive and -negative groups.RESULTS:
Seventy-nine patients aged 60.75 ± 9.66 years old were included 32 were EGFR mutation-positive, and 47 were negative. There were significant differences in pathological stage (P<0.001), tumor diameter (P=0.019), lobulation sign, intrapulmonary metastasis, mediastinal lymph node metastasis, distant metastasis (P<0.001), bone metastasis (P<0.001), arterial phase normalized iodine concentration (NIC) (P=0.001), venous phase NIC (P=0.001), slope of the energy spectrum curve (λ) (P<0.001), and CT value at 70 keV in arterial phase (P=0.004) and venous phase (P=0.003) between the EGFR mutation-positive and -negative patients. The multivariable logistic regression analysis showed that intrapulmonary metastasis, distant metastasis, venous phase NIC, venous phase λ, and pathological stage were independent factors predicting EGFR gene mutations, with high diagnostic power (AUC = 0.975, 91.5% sensitivity, and 90.6% specificity).CONCLUSION:
The pathological stage and the spectral CT parameters of intrapulmonary metastasis, distant metastasis, venous phase NIC, and venous phase λ might pre-operatively predict EGFR gene mutations in intermediate and advanced NSCLC.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada por Rayos X
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Valor Predictivo de las Pruebas
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Carcinoma de Pulmón de Células no Pequeñas
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Receptores ErbB
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Neoplasias Pulmonares
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Mutación
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Radiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China