Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape.
Cell
; 187(13): 3338-3356.e30, 2024 Jun 20.
Article
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| MEDLINE
| ID: mdl-38810644
ABSTRACT
Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species.
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Bases de datos:
MEDLINE
Asunto principal:
Diapausa
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2024
Tipo del documento:
Article