Cerebral Gray Matter May Not Explain Sleep Slow-Wave Characteristics after Severe Brain Injury.
J Neurosci
; 44(32)2024 Aug 07.
Article
en En
| MEDLINE
| ID: mdl-38844342
ABSTRACT
Sleep slow waves are the hallmark of deeper non-rapid eye movement sleep. It is generally assumed that gray matter properties predict slow-wave density, morphology, and spectral power in healthy adults. Here, we tested the association between gray matter volume (GMV) and slow-wave characteristics in 27 patients with moderate-to-severe traumatic brain injury (TBI, 32.0 ± 12.2â
years old, eight women) and compared that with 32 healthy controls (29.2 ± 11.5â
years old, nine women). Participants underwent overnight polysomnography and cerebral MRI with a 3â
Tesla scanner. A whole-brain voxel-wise analysis was performed to compare GMV between groups. Slow-wave density, morphology, and spectral power (0.4-6â
Hz) were computed, and GMV was extracted from the thalamus, cingulate, insula, precuneus, and orbitofrontal cortex to test the relationship between slow waves and gray matter in regions implicated in the generation and/or propagation of slow waves. Compared with controls, TBI patients had significantly lower frontal and temporal GMV and exhibited a subtle decrease in slow-wave frequency. Moreover, higher GMV in the orbitofrontal cortex, insula, cingulate cortex, and precuneus was associated with higher slow-wave frequency and slope, but only in healthy controls. Higher orbitofrontal GMV was also associated with higher slow-wave density in healthy participants. While we observed the expected associations between GMV and slow-wave characteristics in healthy controls, no such associations were observed in the TBI group despite lower GMV. This finding challenges the presumed role of GMV in slow-wave generation and morphology.
Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
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Sustancia Gris
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Lesiones Traumáticas del Encéfalo
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Sueño de Onda Lenta
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurosci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá