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Epigenetic predictors of species maximum life span and other life-history traits in mammals.
Li, Caesar Z; Haghani, Amin; Yan, Qi; Lu, Ake T; Zhang, Joshua; Fei, Zhe; Ernst, Jason; Yang, X William; Gladyshev, Vadim N; Robeck, Todd R; Chavez, Andreas S; Cook, Joseph A; Dunnum, Jonathan L; Raj, Ken; Seluanov, Andrei; Gorbunova, Vera; Horvath, Steve.
Afiliación
  • Li CZ; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Haghani A; Johnson & Johnson Innovative Medicine, Spring House, PA, USA.
  • Yan Q; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Zhang J; Altos Labs, San Diego, CA, USA.
  • Fei Z; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ernst J; Altos Labs, San Diego, CA, USA.
  • Yang XW; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Gladyshev VN; Altos Labs, San Diego, CA, USA.
  • Robeck TR; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Chavez AS; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Cook JA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Dunnum JL; Department of Statistics, University of California, Riverside, Riverside, CA, USA.
  • Raj K; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
  • Seluanov A; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Gorbunova V; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Horvath S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sci Adv ; 10(23): eadm7273, 2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38848365
ABSTRACT
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (R = 0.89), gestation time (R = 0.96), and age at sexual maturity (R = 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric restriction or partial reprogramming. Genetic disruptions in the somatotropic axis such as growth hormone receptors have an impact on DNAm maximum life span only in select tissues. Cancer mortality rates show no correlation with our epigenetic estimates of life-history traits. The DNAm maximum life-span predictor does not detect variation in life span between individuals of the same species, such as between the breeds of dogs. Maximum life span is determined in part by an epigenetic signature that is an intrinsic species property and is distinct from the signatures that relate to individual mortality risk.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética / Longevidad / Mamíferos Límite: Animals / Female / Humans / Male Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética / Longevidad / Mamíferos Límite: Animals / Female / Humans / Male Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos