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Developmental origin of oligodendrocytes determines their function in the adult brain.
Foerster, Sarah; Floriddia, Elisa M; van Bruggen, David; Kukanja, Petra; Hervé, Bastien; Cheng, Shangli; Kim, Eosu; Phillips, Benjamin U; Heath, Christopher J; Tripathi, Richa B; Call, Cody; Bartels, Theresa; Ridley, Katherine; Neumann, Björn; López-Cruz, Laura; Crawford, Abbe H; Lynch, Cian J; Serrano, Manuel; Saksida, Lisa; Rowitch, David H; Möbius, Wiebke; Nave, Klaus-Armin; Rasband, Matthew N; Bergles, Dwight E; Kessaris, Nicoletta; Richardson, William D; Bussey, Timothy J; Zhao, Chao; Castelo-Branco, Gonçalo; Franklin, Robin J M.
Afiliación
  • Foerster S; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Floriddia EM; Altos Labs, Cambridge Institute of Science, Cambridge, UK.
  • van Bruggen D; Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.
  • Kukanja P; Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.
  • Hervé B; Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.
  • Cheng S; Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.
  • Kim E; Ming Wai Lau Centre for Reparative Medicine, Stockholm and Hong Kong nodes, Karolinska Institutet, Stockholm, Sweden.
  • Phillips BU; Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Heath CJ; Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  • Tripathi RB; Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Call C; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
  • Bartels T; School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
  • Ridley K; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Neumann B; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • López-Cruz L; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Crawford AH; Department of Paediatrics, University of Cambridge, Cambridge, UK.
  • Lynch CJ; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Serrano M; Department of Paediatrics, University of Cambridge, Cambridge, UK.
  • Saksida L; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Rowitch DH; Altos Labs, Cambridge Institute of Science, Cambridge, UK.
  • Möbius W; Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Nave KA; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Rasband MN; Altos Labs, Cambridge Institute of Science, Cambridge, UK.
  • Bergles DE; Altos Labs, Cambridge Institute of Science, Cambridge, UK.
  • Kessaris N; Department of Physiology and Pharmacology and Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
  • Richardson WD; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Bussey TJ; Department of Paediatrics, University of Cambridge, Cambridge, UK.
  • Zhao C; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
  • Castelo-Branco G; Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
  • Franklin RJM; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Nat Neurosci ; 2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38849524
ABSTRACT
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity is unknown. Using a genetic strategy to ablate dorsally derived oligodendrocyte lineage cells (OLCs), we show here that the areas in which dorsally derived OLCs normally reside in the adult central nervous system become populated and myelinated by OLCs of ventral origin. These ectopic oligodendrocytes (eOLs) have a distinctive gene expression profile as well as subtle myelination abnormalities. The failure of eOLs to fully assume the role of the original dorsally derived cells results in locomotor and cognitive deficits in the adult animal. This study reveals the importance of developmental heterogeneity within the oligodendrocyte lineage and its importance for homeostatic brain function.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido