Sex-dependent regulation of vertebrate somatic growth and aging by germ cells.
Sci Adv
; 10(24): eadi1621, 2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38865462
ABSTRACT
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Factor I del Crecimiento Similar a la Insulina
/
Células Germinativas
Límite:
Animals
Idioma:
En
Revista:
Sci Adv
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón