microRNA-3037 targeting CYP6CY2 confers imidacloprid resistance to Sitobion miscanthi (Takahashi).
Pestic Biochem Physiol
; 202: 105958, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38879340
ABSTRACT
The wheat aphid Sitobion miscanthi is a dominant and destructive pest in agricultural production. Insecticides are the main substances used for effective control of wheat aphids. However, their extensive application has caused severe resistance of wheat aphids to some insecticides; therefore, exploring resistance mechanisms is essential for wheat aphid management. In the present study, CYP6CY2, a new P450 gene, was isolated and overexpressed in the imidacloprid-resistant strain (SM-R) compared to the imidacloprid-susceptible strain (SM-S). The increased sensitivity of S. miscanthi to imidacloprid after knockdown of CYP6CY2 indicates that it could be associated with imidacloprid resistance. Subsequently, the posttranscriptional regulation of CYP6CY2 in the 3' UTR by miR-3037 was confirmed, and CYP6CY2 participated in imidacloprid resistance. This finding is critical for determining the role of P450 in relation to the resistance of S. miscanthi to imidacloprid. It is of great significance to understand this regulatory mechanism of P450 expression in the resistance of S. miscanthi to neonicotinoids.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Áfidos
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Resistencia a los Insecticidas
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Sistema Enzimático del Citocromo P-450
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MicroARNs
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Neonicotinoides
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Insecticidas
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Nitrocompuestos
Límite:
Animals
Idioma:
En
Revista:
Pestic Biochem Physiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China