Electrochemical detection of nalbuphine drug using oval-like ZnO nanostructure-based sensor.
Anal Biochem
; 693: 115595, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-38909770
ABSTRACT
Monitoring pharmaceutical drugs in various mediums is crucial to mitigate adverse effects. This study presents a chemical sensor using an oval-like zinc oxide (ZnO) nanostructure for electrochemical detection of nalbuphine. The ZnO nanostructure, produced via an efficient sol-gel technique, was extensively characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-visible spectrophotometry, and fourier transform infrared spectroscopy (FTIR). A slurry of the ZnO nanostructure in a binder was applied to a glassy carbon electrode (GCE). The sensor's responsiveness to nalbuphine was assessed using linear sweep voltammetry (LSV), achieving optimal performance by fine-tuning the pH. The sensor demonstrated a proportional response to nalbuphine concentrations up to 150.0 nM with a good regression coefficient (R2) and a detection limit of 6.20 nM (S/N ratio of 3). Selectivity was validated against various interfering substances, and efficacy was confirmed through real sample analysis, highlighting the sensor's successful application for nalbuphine detection.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Óxido de Zinc
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Nanoestructuras
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Electrodos
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Técnicas Electroquímicas
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Nalbufina
Idioma:
En
Revista:
Anal Biochem
Año:
2024
Tipo del documento:
Article
País de afiliación:
Pakistán