Absorption of subcutaneously infused insulin: influence of the basal rate pulse interval.
Diabetes Care
; 8(3): 287-9, 1985.
Article
en En
| MEDLINE
| ID: mdl-3891269
Eight insulin-dependent diabetic patients were given two constant infusions (each 1 IU/h) of 125I-labeled insulin into the abdominal subcutaneous tissue for about 12 h. Insulin was infused in pulses into one side of the abdomen in 6-min intervals (by means of an Auto-Syringe pump) and in the other side of the abdomen, insulin was infused in 1-h intervals (by means of a Medix pump). The size of the subcutaneous depots was continuously measured by counting the radioactivity at the infusion sites. After starting the infusions, the two depots were built up to steady-state levels at the same time and of the same size (approximately 3 IU) and with similar absorption rates. Thus, during basal rate insulin infusion, identical insulin absorption kinetics was achieved, irrespective of a 10-fold difference in the pulse rate.
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Bases de datos:
MEDLINE
Asunto principal:
Sistemas de Infusión de Insulina
/
Diabetes Mellitus Tipo 1
Límite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Diabetes Care
Año:
1985
Tipo del documento:
Article