Sex- and age-related shift of relapse phenotypes in a cohort of relapsing multiple sclerosis patients: Post hoc analysis from the OPERA phase 3 trials.
Eur J Neurol
; 31(10): e16396, 2024 Oct.
Article
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| MEDLINE
| ID: mdl-38925580
ABSTRACT
BACKGROUND AND PURPOSE:
Relapse presentation in relapsing multiple sclerosis (RMS) differs between sexes, leading to differential outcomes. An influence of age seems likely but is less well investigated separately for women and men.METHODS:
Using the large well-defined dataset of the pivotal trials of ocrelizumab in RMS, OPERA I and II, and their open-label extension, we performed a post hoc analysis to investigate relapse phenotypes for sex- and age-related differences in n = 929 relapses in 534 subjects (171 men, 363 women). Frequencies of affected functional systems were analyzed separated by sex and for three age strata (<35, 35-44, ≥45 years). Exact p-values are given for this exploratory analysis.RESULTS:
Frequencies of mono- versus polysymptomatic relapse presentations were different neither between sexes nor in different age groups. Cerebellar symptoms were more frequent in relapses in men (female [f] 23.1%, male [m] 33.0%, p = 0.002), and women's relapses included more sensory (f 53.8%, m 32.3%, p < 0.001) and fatigue symptoms (f 22.6%, m 14.7%, p = 0.006). Whereas the sex difference for sensory involvement was present over all age groups (<35 years f 58.3%, m 30.4%, p < 0.001; 35-44 years f 53.7%, m 36.0%, p = 0.003; ≥45 years f 47.8%, m 28.8%, p = 0.009), the difference for cerebellar involvement diminished with age (<35 years f 20.1%, m 33.3%, p = 0.009; 35-44 years f 22.7%, m 34.2%, p = 0.034; ≥45 years f 27.8%, m 30.3%, p = 0.750). Relapse presentation seemed to shift with age in women only.CONCLUSIONS:
We describe sex-specific relapse presentations and an influence of age only for women. Underlying causal factors warrant further investigations.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fenotipo
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Esclerosis Múltiple Recurrente-Remitente
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Neurol
Asunto de la revista:
NEUROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suiza