Small World derived index to distinguish Alzheimer's type dementia and healthy subjects.
Age Ageing
; 53(6)2024 06 01.
Article
en En
| MEDLINE
| ID: mdl-38935531
ABSTRACT
BACKGROUND:
This article introduces a novel index aimed at uncovering specific brain connectivity patterns associated with Alzheimer's disease (AD), defined according to neuropsychological patterns.METHODS:
Electroencephalographic (EEG) recordings of 370 people, including 170 healthy subjects and 200 mild-AD patients, were acquired in different clinical centres using different acquisition equipment by harmonising acquisition settings. The study employed a new derived Small World (SW) index, SWcomb, that serves as a comprehensive metric designed to integrate the seven SW parameters, computed across the typical EEG frequency bands. The objective is to create a unified index that effectively distinguishes individuals with a neuropsychological pattern compatible with AD from healthy ones.RESULTS:
Results showed that the healthy group exhibited the lowest SWcomb values, while the AD group displayed the highest SWcomb ones.CONCLUSIONS:
These findings suggest that SWcomb index represents an easy-to-perform, low-cost, widely available and non-invasive biomarker for distinguishing between healthy individuals and AD patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Electroencefalografía
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Enfermedad de Alzheimer
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Age Ageing
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia