Correlation Between CT Density, Incidence, Mortality, and Mortality-to-Incidence Ratio in Central Nervous System Cancers: An Exploratory Analysis of Global Data.

ABSTRACT

BACKGROUND/AIM: Cancers of the central nervous system (CNS) pose a significant burden, despite their relatively low incidence compared to other types of cancers. The mortality-to-incidence ratio (MIR) is a crucial indicator of long-term survival and healthcare system performance. Computed tomography (CT) plays a crucial role in the screening, diagnosis, and monitoring of brain tumors, enabling early intervention and treatment. This study aimed to explore the relationship between CT density, CNS cancer incidence, mortality, and MIR to investigate regional variations in CT utilization and their impact on CNS cancer mortality rates. PATIENTS AND METHODS: Changes in MIR, referred to as δMIR, were calculated based on data from 2012 and 2018. CT density data for the year 2013 were retrieved from the Global Health Observatory data repository. The association between variables was analyzed using Spearman's rank correlation coefficient. RESULTS: Analysis of data from 107 countries revealed a positive association between CT density and both CNS cancer incidence and mortality. However, a trend was observed between CT density and MIR. These findings suggest that in countries with greater accessibility to CT imaging, CNS cancer cases may be detected earlier and lower mortality rates can be achieved. CONCLUSION: Our research contributes to the understanding of the impact of CT imaging on the management and outcomes of CNS cancers. It informs healthcare strategies and resource allocation to improve patient care.