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An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.
Tanaka, Shuto; Kawakita, Masataka; Yasui, Hikaru; Sudo, Koichi; Itoh, Fumie; Sasaki, Masato; Shibata, Nobuyuki; Hara, Hiromitsu; Iwakura, Yoichiro; Hashidate-Yoshida, Tomomi; Shindou, Hideo; Shimizu, Takao; Oyama, Taiki; Matsunaga, Himawari; Takahara, Kazuhiko.
Afiliación
  • Tanaka S; Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Kawakita M; Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Yasui H; Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Sudo K; Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Itoh F; Division of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • Sasaki M; Division of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • Shibata N; Division of Infection and Host Defense, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • Hara H; Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Iwakura Y; Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan.
  • Hashidate-Yoshida T; Department of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan.
  • Shindou H; Department of Lipid Life Science, National Center for Global Health and Medicine, Tokyo, Japan.
  • Shimizu T; Department of Medical Lipid Science, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • Oyama T; Department of Lipid Signaling, National Center for Global Health and Medicine, Tokyo, Japan.
  • Matsunaga H; Institute of Microbial Chemistry, Tokyo, Japan.
  • Takahara K; Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Commun Biol ; 7(1): 782, 2024 Jun 29.
Article en En | MEDLINE | ID: mdl-38951147
ABSTRACT
Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and the α2-adrenergic receptor (α2-AR) agonist medetomidine induces lethal damage. Knocking out the C-type lectin Dectin-2 prevents the lethal damage. In spleen, large amounts of platelet-activating factor (PAF) are detected, and knocking out lysophospholipid acyltransferase 9 (LPLAT9/LPCAT2), which encodes an enzyme that converts inactive lyso-PAF to active PAF, protects mice from the lethal damage. These results reveal a linkage/crosstalk between the nervous and the immune system, possibly inducing lethal levels of PAF.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factor de Activación Plaquetaria Límite: Animals Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factor de Activación Plaquetaria Límite: Animals Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Japón