Proton beam therapy and dentofacial development in paediatric cancer patients: A scoping review.
Int J Part Ther
; 12: 100107, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38952615
ABSTRACT
Purpose:
It is known that radiation to dentofacial structures during childhood can lead to developmental disturbances. However, this appears to be a relatively subordinated research subject. For this reason, this review aims to establish the current evidence base on the effect of PBT on dentofacial development in paediatric patients treated for cancer in the head and neck region. Materials andmethods:
A comprehensive search was undertaken to identify both published and unpublished studies or reports. A single reviewer completed initial screening of abstracts; 2 independent reviewers completed secondary screening and data extraction. A narrative synthesis was then conducted.Results:
82 records were screened in total, resulting in 11 included articles. These articles varied in terms of study design and reporting quality. Owing to both poor study reporting and limited patient numbers, it is not possible to determine the effect of cancer diagnosis, chronological age at treatment, radiation dose or treatment modality on the incidence of facial deformation or dental development anomalies.Conclusion:
Disturbances in dentofacial development are an under-reported toxicity in paediatric cancer survivors treated with PBT to the head and neck. There is a need for more research on dentofacial toxicity reporting, focused on the impact of treatment age, radiation dose, concurrent therapies, and the subsequent impact on quality of life.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
Int J Part Ther
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido