Characterization of Mild Delayed Gestational Hypertension in Rats Following Ozone Exposure.
Cardiovasc Toxicol
; 24(9): 843-851, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38963633
ABSTRACT
The contribution of air pollution-induced cardiopulmonary damage on the development of hypertensive disorders of pregnancy and other adverse outcomes of pregnancy has gained increased attention as epidemiological data continue to highlight spatiotemporal pregnancy trends related to air pollution exposure. However clinical mechanistic data surrounding gestational complications remain sparse, necessitating the need for the use of animal models to study these types of complications of pregnancy. The current study seeks to examine the real-time effects of mid-gestational ozone exposure on maternal blood pressure and body temperature through the use of radiotelemetry in a rat model. The exposure resulted in acute depression of heart rate and core body temperature as compared to control animals. Ozone-exposed animals also presented with a slight but significant increase in arterial blood pressure which was perpetuated until term. The data presented here illustrates the feasibility of murine models to assess cardiovascular complications caused by inhaled toxicants during the window of pregnancy.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ozono
/
Hipertensión Inducida en el Embarazo
/
Modelos Animales de Enfermedad
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Frecuencia Cardíaca
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Cardiovasc Toxicol
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
TOXICOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos