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Generation of an induced pluripotent stem cell line (CSBZZUi001-A) from a female Alzheimer's patient carrying the PSEN1 709 T > C heterozygous mutation.
Meng, Xiao-Yan; Sun, Hui-Fang; Zhang, Ying-Jie; Li, Wen-Xiu; Wang, Dian-Dian; Liu, Dan-Hua; Li, Sen-Miao; Wu, Yue; Li, Jia-Kang; Liu, Xiao-Hui; Liu, Pei-Pei; Yang, Run-Zhou; Li, Shu-Ang; Kang, Jian-Sheng.
Afiliación
  • Meng XY; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Sun HF; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000 Zhengzhou, Henan, China.
  • Zhang YJ; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Li WX; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Wang DD; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Liu DH; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Li SM; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Wu Y; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Li JK; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Liu XH; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; The Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University,
  • Liu PP; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Yang RZ; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Li SA; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: lishuanglisen@163.com.
  • Kang JS; Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: kjs@zzu.edu.cn.
Stem Cell Res ; 79: 103486, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38968760
ABSTRACT
Pluripotent stem cells were generated through the electroporation of episomal plasmids, containing crucial reprogramming factors, into skin fibroblasts extracted from a female Alzheimer's patient harboring the PSEN1 709 T > C (p.Phe237Leu) heterozygous mutation. The pluripotent stem cells exhibit a normal karyotype and express pivotal stem cell markers including TRA-1-60, Nanog, SOX2, and OCT4. Furthermore, their capacity to differentiate into the three germ layers in in vivo teratoma experiments has been substantiated. The pluripotent stem cell line can serve as a cellular model for Alzheimer's disease, offering significant value in elucidating the pathogenesis and therapeutic strategies of the disease.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Presenilina-1 / Células Madre Pluripotentes Inducidas / Enfermedad de Alzheimer / Heterocigoto / Mutación Límite: Female / Humans Idioma: En Revista: Stem Cell Res Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Presenilina-1 / Células Madre Pluripotentes Inducidas / Enfermedad de Alzheimer / Heterocigoto / Mutación Límite: Female / Humans Idioma: En Revista: Stem Cell Res Año: 2024 Tipo del documento: Article