Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles.
Proc Natl Acad Sci U S A
; 121(29): e2409605121, 2024 Jul 16.
Article
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| MEDLINE
| ID: mdl-38985768
ABSTRACT
Members of the synaptophysin and synaptogyrin family are vesicle proteins with four transmembrane domains. In spite of their abundance in synaptic vesicle (SV) membranes, their role remains elusive and only mild defects at the cellular and organismal level are observed in mice lacking one or more family members. Here, we show that coexpression with synapsin in fibroblasts of each of the four brain-enriched members of this family-synaptophysin, synaptoporin, synaptogyrin 1, and synaptogyrin 3-is sufficient to generate clusters of small vesicles in the same size range of SVs. Moreover, mice lacking all these four proteins have larger SVs. We conclude that synaptophysin and synaptogyrin family proteins play an overlapping function in the biogenesis of SVs and in determining their small size.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vesículas Sinápticas
/
Sinaptofisina
/
Sinaptogirinas
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2024
Tipo del documento:
Article