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Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.
Stoll, Frederic M; Rudebeck, Peter H.
Afiliación
  • Stoll FM; Nash Family Department of Neuroscience, Lipschultz Center for Cognitive Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 frederic.stoll@mssm.edu.
  • Rudebeck PH; Nash Family Department of Neuroscience, Lipschultz Center for Cognitive Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
J Neurosci ; 44(35)2024 Aug 28.
Article en En | MEDLINE | ID: mdl-38991790
ABSTRACT
The ventral frontal cortex (VFC) in macaques is involved in many affective and cognitive processes and has a key role in flexibly guiding reward-based decision-making. VFC is composed of a set of anatomically distinct subdivisions that are within the orbitofrontal cortex, ventrolateral prefrontal cortex, and anterior insula. In part, because prior studies have lacked the resolution to test for differences, it is unclear if neural representations related to decision-making are dissociable across these subdivisions. Here we recorded the activity of thousands of neurons within eight anatomically defined subdivisions of VFC in male macaque monkeys performing a two-choice probabilistic task for different fruit juice outcomes. We found substantial variation in the encoding of decision variables across these eight subdivisions. Notably, ventrolateral Area 12l was unique relative to the other areas that we recorded from as the activity of single neurons integrated multiple attributes when monkeys evaluated the different choice options. Activity within Area 12o, in contrast, more closely represented reward probability and whether reward was received on a given trial. Orbitofrontal Area 11m/l contained more specific representations of the quality of the outcome that could be earned later on. We also found that reward delivery encoding was highly distributed across all VFC subdivisions, while the properties of the reward, such as its flavor, were more strongly represented in Areas 11m/l and 13m. Taken together, our work reveals the diversity of encoding within the various anatomically distinct subdivisions of VFC in primates.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Recompensa / Toma de Decisiones / Lóbulo Frontal / Macaca mulatta Límite: Animals Idioma: En Revista: J Neurosci / J. neurosci / Journal of neuroscience Año: 2024 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Recompensa / Toma de Decisiones / Lóbulo Frontal / Macaca mulatta Límite: Animals Idioma: En Revista: J Neurosci / J. neurosci / Journal of neuroscience Año: 2024 Tipo del documento: Article