Association between Peripheral Arterial Lactate Levels and Malignant Brain Edema Following Endovascular Treatment for Ischemic Stroke.
Curr Neurovasc Res
; 20(5): 535-543, 2024.
Article
en En
| MEDLINE
| ID: mdl-39004958
ABSTRACT
AIMS:
To investigate the factors of postoperative malignant brain edema (MBE) in patients with acute ischemic stroke (AIS) treated with endovascular treatment (EVT).BACKGROUND:
MBE is a severe complication following EVT for AIS, and it is essential to identify risk factors early. Peripheral arterial lactate (PAL) levels may serve as a potential predictive marker for MBE.OBJECTIVE:
To determine whether immediate postoperative PAL levels and the highest PAL level within 24 hours of EVT are independently associated with MBE development in AIS patients.METHODS:
We retrospectively analyzed patients with AIS who underwent EVT from October 2019 to October 2022. Arterial blood was collected every 8 h after EVT to measure PAL, and record the immediate postoperative PAL and the highest PAL level within 24 h. Brain edema was evaluated using brain computed tomography scans within 7 days of EVT.RESULTS:
The study included 227 patients with a median age of 71 years, of whom 59.5% were male and MBE developed in 25.6% of patients (58/227). Multivariate logistic regression analysis showed that the immediate postoperative PAL (odds ratio, 1.809 [95% confidence interval (CI), 1.215-2.693]; p = 0.004) and the highest PAL level within 24 h of EVT (odds ratio, 2.259 [95% CI, 1.407-3.629]; p = 0.001) were independently associated with MBE. The area under the curve for predicting MBE based on the highest PAL level within 24 hours of EVT was 0.780 (95% CI, 0.711-0.849).CONCLUSION:
Early increase in PAL levels is an independent predictor of MBE after EVT in AIS patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Edema Encefálico
/
Ácido Láctico
/
Procedimientos Endovasculares
/
Accidente Cerebrovascular Isquémico
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Curr Neurovasc Res
Asunto de la revista:
ANGIOLOGIA
/
NEUROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China