Direct 3D printing of freeform anisotropic bioactive structure based on shear-oriented ink system.
Biofabrication
; 16(4)2024 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-39008993
ABSTRACT
Various anisotropic tissue structures exist in organisms, including muscle tissue, skin tissue, and nerve tissue. Replicating anisotropic tissue structuresin vitrohas posed a significant challenge. Three-dimensional (3D) printing technology is often used to fabricate biomimetic structures due to its advantages in manufacturing principle. However, direct 3D printing of freeform anisotropic bioactive structures has not been reported. To tackle this challenge, we developed a ternary F/G/P ink system that integrates the printability of Pluronic F127 (F), the robust bioactivity and photocrosslinking properties of gelatin methacryloyl (G), and the shear-induced alignment functionality of high-molecular-weight polyethylene glycol (P). And through this strategic ternary system combination, freeform anisotropic tissue structures can be 3D printed directly. Moreover, these anisotropic structures exhibit excellent bioactivity, and promote orientational growth of different cells. This advancement holds promise for the repair and replacement of anisotropic tissues within the human body.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poloxámero
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Andamios del Tejido
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Impresión Tridimensional
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Gelatina
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Tinta
Límite:
Animals
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Humans
Idioma:
En
Revista:
Biofabrication
Asunto de la revista:
BIOTECNOLOGIA
Año:
2024
Tipo del documento:
Article