Emerging platelet-based drug delivery systems.
Biomed Pharmacother
; 177: 117131, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39013224
ABSTRACT
Drug delivery systems are becoming increasingly utilized; however, a major challenge in this field is the insufficient target of tissues or cells. Although efforts with engineered nanoparticles have shown some success, issues with targeting, toxicity and immunogenicity persist. Conversely, living cells can be used as drug-delivery vehicles because they typically have innate targeting mechanisms and minimal adverse effects. As active participants in hemostasis, inflammation, and tumors, platelets have shown great potential in drug delivery. This review highlights platelet-based drug delivery systems, including platelet membrane engineering, platelet membrane coating, platelet cytoplasmic drug loading, genetic engineering, and synthetic/artificial platelets for different applications.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Sistemas de Liberación de Medicamentos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Año:
2024
Tipo del documento:
Article