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Incidence and Prevalence of Early-Onset Dementia in Finland.
Krüger, Johanna; Aaltonen, Mikko; Aho, Kalle; Heikkinen, Sami; Kivisild, Ave; Lehtonen, Adolfina; Leppänen, Laura; Rinnankoski, Iina; Soppela, Helmi; Tervonen, Laura; Suhonen, Noora-Maria; Haapasalo, Annakaisa; Portaankorva, Anne M; Mäki-Petäjä-Leinonen, Anna; Hartikainen, Päivi; Katisko, Kasper; Solje, Eino.
Afiliación
  • Krüger J; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Aaltonen M; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Aho K; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Heikkinen S; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Kivisild A; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Lehtonen A; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Leppänen L; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Rinnankoski I; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Soppela H; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Tervonen L; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Suhonen NM; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Haapasalo A; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Portaankorva AM; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Mäki-Petäjä-Leinonen A; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Hartikainen P; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Katisko K; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
  • Solje E; From the Research Unit of Clinical Medicine (J.K., A.L., L.L., I.R., L.T., N.-M.S.), Neurology, University of Oulu; MRC (J.K., L.T., N.-M.S.); Neurocenter (J.K., L.T., N.-M.S.), Neurology, Oulu University Hospital; Law School (M.A., A.M.-P.-L.), University of Eastern Finland, Joensuu; Institute of C
Neurology ; 103(4): e209654, 2024 Aug 27.
Article en En | MEDLINE | ID: mdl-39047214
ABSTRACT

OBJECTIVES:

Current epidemiologic data of early-onset dementia (EOD), characterized by the onset of the disease before the age of 65, are notably scarce.

METHODS:

We evaluated the incidence (from January 2010 to December 2021) and prevalence (on December 31, 2021) of EOD and its subtypes in 2 defined areas in Finland. All visits at the dementia outpatient clinics were manually retrospectively reviewed and reassessed (N = 12,490).

RESULTS:

In the population aged ≤65 years, crude incidence of EOD was 12.3/100,000 persons at risk/year based on 794 new cases from January 1, 2010, to December 31, 2021. Incidence rates for EOD were 20.5 and 33.7 per 100,000 person years in the age group of 30-64 and 45-64 years, respectively. The prevalence of EOD was 110.4 in the age group of 30-64 years and 190.3 in the age group 45-64. Alzheimer disease (AD) (48.2%) and behavioral variant frontotemporal dementia (12.7%) were the most frequent subtypes. The incidence of AD increased during the follow-up, whereas incidence of other forms of EOD remained stable.

DISCUSSION:

We found higher incidence rates of EOD than previously reported. Unlike other forms of EOD, the incidence of early-onset AD seems to be increasing.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Edad de Inicio / Demencia Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Neurology Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Edad de Inicio / Demencia Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Neurology Año: 2024 Tipo del documento: Article