Characteristics and mechanisms of T-cell senescence: A potential target for cancer immunotherapy.
Eur J Immunol
; : e2451093, 2024 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-39107923
ABSTRACT
Immunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age-related T-cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age-associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age-related diseases and enhance tumor immunotherapy efficacy.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Eur J Immunol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China