The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex.
J Nutr
; 2024 Aug 08.
Article
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| MEDLINE
| ID: mdl-39122089
ABSTRACT
BACKGROUND:
Previous studies reported that vitamin B-12 deficiency is associated with an increased risk of stroke. However, studies examining the association between excessive vitamin B-12 and stroke risk are limited. Our study aimed to investigate the relationship between excessive vitamin B-12 concentrations and risk of stroke and explore whether this association varies according to sex.METHODS:
Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were vitamin B-12 plasma concentration and sex. The occurrence of stroke served as the main outcome of interest. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis. An interaction analysis was conducted to assess the interaction effect of vitamin B-12 and sex on stroke incidence.RESULTS:
Cox proportional logistic regression analysis, adjusting for confounders, showed that excessive vitamin B-12 did not significantly alter stroke risk (HR 1.22, 95% CI 0.82, 1.71) and revealed no significant sex-based differences in stroke risk (HR 0.90, 95% CI 0.75, 1.04). However, interaction analysis indicated that excessive vitamin B-12 was linked to a significant increase in stroke risk in males (HR 1.81, 95% CI 1.10, 2.99) but not in females (HR 1.04, 95% CI 0.66, 1.60), with statistically significant interaction effect (P < 0.01).CONCLUSIONS:
Our study demonstrated that although excessive vitamin B-12 alone does not significantly increase stroke risk, it increases risk in males when considering the interaction with sex.
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MEDLINE
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Revista:
J Nutr
Año:
2024
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Article