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MitoAMPK inhibits the Warburg effect by MZF1-SIRT6 with glycosis related genes in NSCLC.
Li, Shangyu; He, Jinyao; Zhang, Lijie; Zhao, Qiaojiajie; Zhao, Shuqi; Jiang, Shanshan.
Afiliación
  • Li S; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, China.
  • He J; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, China.
  • Zhang L; Department of Clinical Laboratory Diagnostics, Xi'an Medical University, Xi'an, China.
  • Zhao Q; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, China.
  • Zhao S; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, China.
  • Jiang S; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, China.
J Cell Mol Med ; 28(17): e70053, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39224032
ABSTRACT
MitoAMPK was proved to inhibit the Warburg effect, but the specific mechanisms on non-small-cell lung cancer remain unclear. Here, we selected SIRT6 and MZF1 to clarify the mechanism. By western blotting, quantitative polymerase chain reaction, the CCK-8 assay, and immunohistochemistry assays, we found SIRT6 expression was lower in NSCLC tissues and cell lines than normal tissues and cells. Moreover, SIRT6 could inhibit the Warburg effect by regulating glycolysis-related genes of SLC2A2, SLC2A4 and PKM2. Finally, we demonstrated the interaction between SIRT6 and MZF1 using ChIP-qPCR. In conclusion, mitoAMPK inhibits the Warburg effect by regulating the expression of the MZF1-SIRT6 complex.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Carcinoma de Pulmón de Células no Pequeñas / Sirtuinas / Factores de Transcripción de Tipo Kruppel / Efecto Warburg en Oncología / Neoplasias Pulmonares Límite: Female / Humans / Male Idioma: En Revista: J Cell Mol Med / J. cell. mol. med / Journal of cellular and molecular medicine Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Carcinoma de Pulmón de Células no Pequeñas / Sirtuinas / Factores de Transcripción de Tipo Kruppel / Efecto Warburg en Oncología / Neoplasias Pulmonares Límite: Female / Humans / Male Idioma: En Revista: J Cell Mol Med / J. cell. mol. med / Journal of cellular and molecular medicine Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China