Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.
Photodermatol Photoimmunol Photomed
; 40(6): e13001, 2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-39368082
ABSTRACT
BACKGROUND:
Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM2.5) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.METHODS:
This study sought to assess the protective effects of butin against damage triggered by PM2.5 and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.RESULTS:
Butin exhibited its protective ability via the inhibition of PM2.5-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM2.5-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM2.5- and UVB-induced apoptosis.CONCLUSION:
Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM2.5 and UVB exposure.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Rayos Ultravioleta
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Daño del ADN
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Queratinocitos
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Apoptosis
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Material Particulado
Límite:
Humans
Idioma:
En
Revista:
Photodermatol Photoimmunol Photomed
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
DERMATOLOGIA
Año:
2024
Tipo del documento:
Article