Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis.
Cancer
; 57(7): 1313-7, 1986 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-3948114
Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Antígeno H-Y
/
Disgerminoma
/
Neoplasias de los Genitales Femeninos
/
Disgenesia Gonadal
/
Disgenesia Gonadal 46 XY
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cancer
Año:
1986
Tipo del documento:
Article