Indomethacin and the corneal immune response.
Am J Ophthalmol
; 81(5): 650-5, 1976 May.
Article
en En
| MEDLINE
| ID: mdl-58559
ABSTRACT
To study the effect of treating rabbits with a locally administered noncorticosteroid anti-inflammatory drug, we gave 26 rabbits unilateral subconjunctival injections of 15 mg of indomethacin suspension daily for 16 days, starting one day before the intracorneal injection of the same eye with bovine gamma globulin. We graded the eyes clinically and killed groups of rabbits on postimmunization days 6, 9, 12, and 15. We determined the number of antibody-forming cells in the homolateral cervical lymph nodes, corneas, and uveal tracts and tested the sera, aqueous humor, and vitreous humor for antibodies. Indomethacin-treated eyes showed significantly less inflammatory response, and an insignificantly greater number of antibody-forming cells, than the controls.
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Bases de datos:
MEDLINE
Asunto principal:
Indometacina
/
Córnea
/
Formación de Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
Am J Ophthalmol
Año:
1976
Tipo del documento:
Article