The role of pre-synaptic GABA and benzodiazepine receptors in the control of noradrenaline release in rat hippocampus.
Neurosci Lett
; 42(1): 61-6, 1983 Nov 21.
Article
en En
| MEDLINE
| ID: mdl-6318164
ABSTRACT
Noradrenaline release from synaptosomes of rat hippocampus is modulated by both GABA and benzodiazepines. GABAA and GABAB receptors are present on these nerve terminals, and agonists at these receptors enhance spontaneous release and depress K+ -evoked release, respectively. Chlordiazepoxide has a dual effect it enhances the action of GABA at GABAA receptors and depresses K+ -evoked release of [3H]noradrenaline in the absence of GABA. The mechanism of these actions and their in vivo role are discussed.
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Bases de datos:
MEDLINE
Asunto principal:
Norepinefrina
/
Receptores de Superficie Celular
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1983
Tipo del documento:
Article