Regulation of the anti-inulin antibody response by a nonallotype-linked gene.
J Exp Med
; 151(5): 1088-102, 1980 May 01.
Article
en En
| MEDLINE
| ID: mdl-6768829
ABSTRACT
The antibody response to the inulin [(In), beta-(2 leads to 1) fructosan] determinant of bacterial levan [(BL), a beta-(2 leads to 6) polyfructosan that contains beta-(2 leads to 1) branch points] requires the presence of the a haplotype of the Igh gene complex. BALB/c (Igh a) mice immunized with BL produce IgG anti-In antibodies of a single spectrotype by isoelectric focusing analysis. C57BL/6 mice, which possess the b haplotype of the Igh gene complex and which fail to produce anti-In antibodies, nevertheless possess a gene, spectrotype regulation gene 1 (Sr-1), that regulates the isoelectric focusing (IEF) pattern of anti-In antibodies in mice of the a haplotype. Thus, the IEF patterns of anti-In antibodies of (BALB/c x C57BL/6)F1 mice and of B.C8 mice (C57BL/Ka . Igh-Ca) are considerably more complex than those of BALB/c. Backcross analysis indicates that Sr-1 is not linked to the Igh complex, the major histocompatibility complex, or to the genes that code for coat color. Studies of the heterogeneity of anti-In antibodies in recombinant inbred lines and their progeny from matings to BALB/c and C.B20 (BALB/c . Igh-Cb) suggest the existence of other regulatory genes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polisacáridos
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Inmunoglobulina G
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Genes Reguladores
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Genes MHC Clase II
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Fructanos
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Inulina
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Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1980
Tipo del documento:
Article